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An altered CD8(+) T cell epitope of insulin prevents type 1 diabetes in humanized NOD mice
Autoreactive CD8(+) T cells, which play an indispensable role in β cell destruction, represent an emerging target for the prevention of type 1 diabetes (T1D). Altered peptide ligands (APLs) can efficiently induce antigen-specific T cells anergy, apoptosis or shifts in the immune response. Here, we f...
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| Publicado no: | Cell Mol Immunol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6804845/ https://ncbi.nlm.nih.gov/pubmed/29955175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0058-3 |
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