Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression

Purpose: Morbidity associated with and mortality from acute kidney injury (AKI) is gradually increasing, and no efficient drug is available. We explored whether neferine, a bisbenzylisoquinoline alkaloid, attenuated AKI, and the possible mechanisms in play in vivo and in vitro. Methods: We induced A...

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Vydáno v:Front Pharmacol
Hlavní autoři: Li, Huihui, Chen, Wenhang, Chen, Yusa, Zhou, Qiaoling, Xiao, Ping, Tang, Rong, Xue, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804424/
https://ncbi.nlm.nih.gov/pubmed/31680971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01197
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