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Coetaneous catalytic kinetic resolution of alkynes and azides through asymmetric triazole formation

A non-enzymatic simultaneous (coined coetaneous) kinetic resolution of a racemic alkyne and racemic azide, utilising an asymmetric CuAAC reaction is reported. The use of a CuCl (R,R)-Ph-Pybox catalyst system effects a simultaneous kinetic resolution of two racemic starting materials to give one majo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Brittain, William D. G., Dalling, Andrew G., Sun, Zhenquan, Duff, Cécile S. Le, Male, Louise, Buckley, Benjamin R., Fossey, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803658/
https://ncbi.nlm.nih.gov/pubmed/31636274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50940-4
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