Genome-Wide Analysis of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) Binding to HIV-1 RNA Reveals a Key Role for hnRNP H1 in Alternative Viral mRNA Splicing

Alternative splicing of HIV-1 mRNAs increases viral coding potential and controls the levels and timing of gene expression. HIV-1 splicing is regulated in part by heterogeneous nuclear ribonucleoproteins (hnRNPs) and their viral target sequences, which typically repress splicing when studied outside...

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Udgivet i:J Virol
Main Authors: Kutluay, Sebla B., Emery, Ann, Penumutchu, Srinivasa R., Townsend, Dana, Tenneti, Kasyap, Madison, Michaela K., Stukenbroeker, Amanda M., Powell, Chelsea, Jannain, David, Tolbert, Blanton S., Swanstrom, Ronald I., Bieniasz, Paul D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803249/
https://ncbi.nlm.nih.gov/pubmed/31413137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01048-19
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