In Vitro Performance of Published Glypican 3-Targeting Peptides TJ12P1 and L5 Indicates Lack of Specificity and Potency

Background: Glypican 3 (GPC3), a plasma membrane heparan sulfate proteoglycan, is overexpressed on human hepatocellular carcinoma and may represent a promising biomarker. Several studies have reported peptides that selectively bind to GPC3 and could serve as scaffolds for imaging or therapeutic agen...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Biother Radiopharm
Hauptverfasser: Berman, Rose M., Kelada, Olivia J., Gutsche, Nicholas T., Natarajan, Raju, Swenson, Rolf E., Fu, Ying, Hong, Jessica, Ho, Mitchell, Choyke, Peter L., Escorcia, Freddy E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802730/
https://ncbi.nlm.nih.gov/pubmed/31424293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2019.2888
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