Glypican-3-Targeted Alpha Particle Therapy for Hepatocellular Carcinoma

Glypican-3 (GPC3) is expressed in 75% of hepatocellular carcinoma (HCC), but not normal liver, making it a promising HCC therapeutic target. GC33 is a full-length humanized monoclonal IgG1 specific to GPC3 that can localize to HCC in vivo. GC33 alone failed to demonstrate therapeutic efficacy when e...

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Detaylı Bibliyografya
Yayımlandı:Molecules
Asıl Yazarlar: Bell, Meghan M., Gutsche, Nicholas T., King, A. Paden, Baidoo, Kwamena E., Kelada, Olivia J., Choyke, Peter L., Escorcia, Freddy E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792624/
https://ncbi.nlm.nih.gov/pubmed/33374953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26010004
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