Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation

Dyslipidemia-induced atherosclerosis, which has a risk of high morbidity and mortality, can be alleviated by metabolic activation associated with mitochondrial function. The effect of dichloroacetate (DCA), a general pyruvate dehydrogenase kinase (PDK) inhibitor, on in vivo energy expenditure in Apo...

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Veröffentlicht in:Exp Mol Med
Hauptverfasser: Min, Byong-Keol, Oh, Chang Joo, Park, Sungmi, Lee, Ji-Min, Go, Younghoon, Park, Bo-Yoon, Kang, Hyeon-Ji, Kim, Dong Wook, Kim, Jeong-Eun, Yoo, Eun Kyung, Kim, Hui Eon, Kim, Mi-Jin, Jeon, Yong Hyun, Kim, Yong-Hoon, Lee, Chul-Ho, Jeon, Jae-Han, Lee, In-Kyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802614/
https://ncbi.nlm.nih.gov/pubmed/31570705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0315-2
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