The transferrin receptor CD71 regulates type II CD38, revealing tight topological compartmentalization of intracellular cyclic ADP-ribose production

The CD38 molecule (CD38) catalyzes biogenesis of the calcium-mobilizing messenger cyclic ADP-ribose (cADPR). CD38 has dual membrane orientations, and type III CD38, with its catalytic domain facing the cytosol, has low abundance but is efficient in cyclizing cytosolic NAD to produce cADPR. The role...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Deng, Qi Wen, Zhang, Jingzi, Li, Ting, He, Wei Ming, Fang, Lei, Lee, Hon Cheung, Zhao, Yong Juan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802523/
https://ncbi.nlm.nih.gov/pubmed/31434741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010010
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