Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells

The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na(+) and water transport in leaky epithelia and alters cancer cell proliferation. Previously, we reported that tumor necrosis factor-α time-dependently alters CLDN-2 expression in tubular epithelial cells. Here, we f...

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Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Dan, Qinghong, Shi, Yixuan, Rabani, Razieh, Venugopal, Shruthi, Xiao, Jenny, Anwer, Shaista, Ding, Mei, Speight, Pam, Pan, Wanling, Alexander, R. Todd, Kapus, András, Szászi, Katalin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802501/
https://ncbi.nlm.nih.gov/pubmed/31481470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006484
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