Profibrotic epithelial phenotype: a central role for MRTF and TAZ

Epithelial injury is a key initiator of fibrosis but - in contrast to the previous paradigm - the epithelium in situ does not undergo wide-spread epithelial-mesenchymal/myofibroblast transition (EMT/EMyT). Instead, it assumes a Profibrotic Epithelial Phenotype (PEP) characterized by fibrogenic cytok...

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Publicat a:Sci Rep
Autors principals: Bialik, Janne Folke, Ding, Mei, Speight, Pam, Dan, Qinghong, Miranda, Maria Zena, Di Ciano-Oliveira, Caterina, Kofler, Michael M., Rotstein, Ori D., Pedersen, Stine F., Szászi, Katalin, Kapus, András
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416270/
https://ncbi.nlm.nih.gov/pubmed/30867502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40764-7
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