Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

BACKGROUND: Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemotherapy and is a positive predictive marker of immunotherapy,...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Johansen, Amanda Frydendahl Boll, Kassentoft, Christine Gaasdal, Knudsen, Michael, Laursen, Maria Bach, Madsen, Anders Husted, Iversen, Lene Hjerrild, Sunesen, Kåre Gotschalck, Rasmussen, Mads Heilskov, Andersen, Claus Lindbjerg
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802299/
https://ncbi.nlm.nih.gov/pubmed/31638937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6227-7
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