Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

IMPORTANCE: Norepinephrine, the first-line vasopressor for septic shock, is not always effective and has important catecholaminergic adverse effects. Selepressin, a selective vasopressin V1a receptor agonist, is a noncatecholaminergic vasopressor that may mitigate sepsis-induced vasodilatation, vasc...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:JAMA
المؤلفون الرئيسيون: Laterre, Pierre-Francois, Berry, Scott M., Blemings, Allan, Carlsen, Jan E., François, Bruno, Graves, Todd, Jacobsen, Karsten, Lewis, Roger J., Opal, Steven M., Perner, Anders, Pickkers, Peter, Russell, James A., Windeløv, Nis A., Yealy, Donald M., Asfar, Pierre, Bestle, Morten H., Muller, Grégoire, Bruel, Cédric, Brulé, Noëlle, Decruyenaere, Johan, Dive, Alain-Michel, Dugernier, Thierry, Krell, Kenneth, Lefrant, Jean-Yves, Megarbane, Bruno, Mercier, Emmanuelle, Mira, Jean-Paul, Quenot, Jean-Pierre, Rasmussen, Bodil Steen, Thorsen-Meyer, Hans-Christian, Vander Laenen, Margot, Vang, Marianne Lauridsen, Vignon, Philippe, Vinatier, Isabelle, Wichmann, Sine, Wittebole, Xavier, Kjølbye, Anne Louise, Angus, Derek C.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Medical Association 2019
الموضوعات:
Original Investigation
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802260/
https://ncbi.nlm.nih.gov/pubmed/31577035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.14607
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