Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

IMPORTANCE: Norepinephrine, the first-line vasopressor for septic shock, is not always effective and has important catecholaminergic adverse effects. Selepressin, a selective vasopressin V1a receptor agonist, is a noncatecholaminergic vasopressor that may mitigate sepsis-induced vasodilatation, vasc...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Laterre, Pierre-Francois, Berry, Scott M., Blemings, Allan, Carlsen, Jan E., François, Bruno, Graves, Todd, Jacobsen, Karsten, Lewis, Roger J., Opal, Steven M., Perner, Anders, Pickkers, Peter, Russell, James A., Windeløv, Nis A., Yealy, Donald M., Asfar, Pierre, Bestle, Morten H., Muller, Grégoire, Bruel, Cédric, Brulé, Noëlle, Decruyenaere, Johan, Dive, Alain-Michel, Dugernier, Thierry, Krell, Kenneth, Lefrant, Jean-Yves, Megarbane, Bruno, Mercier, Emmanuelle, Mira, Jean-Paul, Quenot, Jean-Pierre, Rasmussen, Bodil Steen, Thorsen-Meyer, Hans-Christian, Vander Laenen, Margot, Vang, Marianne Lauridsen, Vignon, Philippe, Vinatier, Isabelle, Wichmann, Sine, Wittebole, Xavier, Kjølbye, Anne Louise, Angus, Derek C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802260/
https://ncbi.nlm.nih.gov/pubmed/31577035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.14607
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