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Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake

Cancer-derived small extracellular vesicles (sEVs) induce stromal cells to become permissive for tumor growth. However, it is unclear whether this induction solely occurs through transfer of vesicular cargo into recipient cells. Here we show that cancer-derived sEVs can stimulate endothelial cell mi...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Ko, Song Yi, Lee, WonJae, Kenny, Hilary A., Dang, Long H., Ellis, Lee M., Jonasch, Eric, Lengyel, Ernst, Naora, Honami
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802217/
https://ncbi.nlm.nih.gov/pubmed/31646189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0609-x
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