Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake

Cancer-derived small extracellular vesicles (sEVs) induce stromal cells to become permissive for tumor growth. However, it is unclear whether this induction solely occurs through transfer of vesicular cargo into recipient cells. Here we show that cancer-derived sEVs can stimulate endothelial cell mi...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Ko, Song Yi, Lee, WonJae, Kenny, Hilary A., Dang, Long H., Ellis, Lee M., Jonasch, Eric, Lengyel, Ernst, Naora, Honami
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802217/
https://ncbi.nlm.nih.gov/pubmed/31646189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0609-x
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