Structure-Based Design and in Silico Screening of Virtual Combinatorial Library of Benzamides Inhibiting 2-trans Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Predicted Pharmacokinetic Profiles

Background: During the previous decade a new class of benzamide-based inhibitors of 2-trans enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (Mt) with unusual binding mode have emerged. Here we report in silico design and evaluation of novel benzamide InhA-Mt inhibitors with...

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Publicado no:Int J Mol Sci
Main Authors: Kouman, Koffi Charles, Keita, Melalie, Kre N’Guessan, Raymond, Owono Owono, Luc Calvin, Megnassan, Eugene, Frecer, Vladimir, Miertus, Stanislav
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802012/
https://ncbi.nlm.nih.gov/pubmed/31554227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194730
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