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Computer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles

We have carried out a computational structure-based design of new potent pyrrolidine carboxamide (PCAMs) inhibitors of enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (MTb). Three-dimensional (3D) models of InhA-PCAMx complexes were prepared by in situ modification of the c...

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Xehetasun bibliografikoak
Argitaratua izan da:Int J Mol Sci
Egile Nagusiak: Kouassi, Affiba Florance, Kone, Mawa, Keita, Melalie, Esmel, Akori, Megnassan, Eugene, N’Guessan, Yao Thomas, Frecer, Vladimir, Miertus, Stanislav
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691139/
https://ncbi.nlm.nih.gov/pubmed/26703572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms161226196
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