Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing

Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the origin of two of these stresses, namely mitochondrial metabolic compromise, associated with reactive oxygen species (ROS) production, and replicative senescence, activated by extreme telomere shortening. We di...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Billard, Pauline, Poncet, Delphine A
Format: Artigo
Language:Inglês
Published: MDPI 2019
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801922/
https://ncbi.nlm.nih.gov/pubmed/31597307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194959
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