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Biophysical characterization and modulation of Transthyretin Ala97Ser
OBJECTIVE: Ala97Ser (A97S) is the major transthyretin (TTR) mutation in Taiwanese patients of familial amyloid polyneuropathy (FAP), characterized by a late‐onset but rapidly deteriorated neuropathy. Tafamidis can restore the stability of some mutant TTR tetramers and slow down the progression of TT...
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| Publicat a: | Ann Clin Transl Neurol |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6801203/ https://ncbi.nlm.nih.gov/pubmed/31502419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.50887 |
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