Germline-encoded affinity for cognate antigen enables vaccine-amplification of a human broadly neutralizing response against influenza virus

Antibody paratopes are formed by hypervariable complementarity-determining regions (CDRH3s) and variable gene-encoded CDRs. The latter shows biased usage in human broadly neutralizing antibodies (bnAbs) against both HIV and influenza virus, suggesting the existence of gene-endowed targeting solution...

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Publicado no:Immunity
Main Authors: Sangesland, Maya, Ronsard, Larance, Kazer, Samuel W., Bals, Julia, Boyoglu-Barnum, Seyhan, Yousif, Ashraf S., Barnes, Ralston, Feldman, Jared, Quirindongo-Crespo, Maricel, McTamney, Patrick. M., Rohrer, Daniel, Lonberg, Nils, Chackerian, Bryce, Graham, Barney S., Kanekiyo, Masaru, Shalek, Alex K., Lingwood, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801110/
https://ncbi.nlm.nih.gov/pubmed/31563464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.09.001
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