Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS

Sulfonate esters have been recognized as potential genotoxic impurities (PGIs) in pharmaceuticals. An LC-MS/MS method was developed and validated for the simultaneous determination of 15 sulfonate esters, including methyl, ethyl, propyl, isopropyl, and n-butyl esters of methanesulfonate, benzenesulf...

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Bibliographic Details
Published in:J Anal Methods Chem
Main Authors: Jin, Bo, Guo, Kaijing, Zhang, Tingting, Li, Tong, Ma, Chen
Format: Artigo
Language:Inglês
Published: Hindawi 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800909/
https://ncbi.nlm.nih.gov/pubmed/31687249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/4059765
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