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Mutant L-Chain Ferritins that Cause Neuroferritinopathy Significantly Alter Ferritin Functionality and Iron Permeability

In mammals, the iron storage and detoxification protein ferritin is composed of two functionally and genetically distinct subunit types, H (Heavy) and L (Light). The two subunits co-assemble in various ratios, with a tissue specific distribution, to form shell-like protein structures of 24 subunits...

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Detalhes bibliográficos
Publicado no:Metallomics
Main Authors: Mehlenbacher, Matthew R, McNally, Justin R, Luscieti, Sara, Smith, Gideon L, Reutovich, Aliaksandra A, Maura, Poli, Arosio, Paolo, Bou-Abdallah, Fadi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800815/
https://ncbi.nlm.nih.gov/pubmed/31513212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9mt00154a
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