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Mutant L-Chain Ferritins that Cause Neuroferritinopathy Significantly Alter Ferritin Functionality and Iron Permeability

In mammals, the iron storage and detoxification protein ferritin is composed of two functionally and genetically distinct subunit types, H (Heavy) and L (Light). The two subunits co-assemble in various ratios, with a tissue specific distribution, to form shell-like protein structures of 24 subunits...

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Bibliografiske detaljer
Udgivet i:Metallomics
Main Authors: Mehlenbacher, Matthew R, McNally, Justin R, Luscieti, Sara, Smith, Gideon L, Reutovich, Aliaksandra A, Maura, Poli, Arosio, Paolo, Bou-Abdallah, Fadi
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800815/
https://ncbi.nlm.nih.gov/pubmed/31513212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9mt00154a
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