Mutant L-Chain Ferritins that Cause Neuroferritinopathy Significantly Alter Ferritin Functionality and Iron Permeability

In mammals, the iron storage and detoxification protein ferritin is composed of two functionally and genetically distinct subunit types, H (Heavy) and L (Light). The two subunits co-assemble in various ratios, with a tissue specific distribution, to form shell-like protein structures of 24 subunits...

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Vydáno v:Metallomics
Hlavní autoři: Mehlenbacher, Matthew R, McNally, Justin R, Luscieti, Sara, Smith, Gideon L, Reutovich, Aliaksandra A, Maura, Poli, Arosio, Paolo, Bou-Abdallah, Fadi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800815/
https://ncbi.nlm.nih.gov/pubmed/31513212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9mt00154a
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