Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

Genome editing using the CRISPR/Cas9 system has been used to make precise heritable changes in the DNA of organisms. Although the widely used Streptococcus pyogenes Cas9 (SpCas9) and its engineered variants have been efficiently harnessed for numerous gene-editing applications across different platf...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Acharya, Sundaram, Mishra, Arpit, Paul, Deepanjan, Ansari, Asgar Hussain, Azhar, Mohd., Kumar, Manoj, Rauthan, Riya, Sharma, Namrata, Aich, Meghali, Sinha, Dipanjali, Sharma, Saumya, Jain, Shivani, Ray, Arjun, Jain, Suman, Ramalingam, Sivaprakash, Maiti, Souvik, Chakraborty, Debojyoti
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800334/
https://ncbi.nlm.nih.gov/pubmed/31570623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818461116
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