The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer

The ubiquitin-proteasome pathway plays an important role in the regulation of cellular proteins. As an alternative to the proteasome itself, recent research has focused on methods to modulate the regulation of deubiquitinating enzymes (DUBs) upstream of the proteasome, identifying DUBs as novel ther...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fukui, Shiho, Nagasaka, Kazunori, Miyagawa, Yuko, Kikuchi-Koike, Ryoko, Kawata, Yoshiko, Kanda, Ranka, Ichinose, Takayuki, Sugihara, Takeru, Hiraike, Haruko, Wada-Hiraike, Osamu, Sasajima, Yuko, Ayabe, Takuya
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800272/
https://ncbi.nlm.nih.gov/pubmed/31666925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27219
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