Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls

Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture. This association is particularly strong in postmenopausal women, in whom net...

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Vydáno v:Bone
Hlavní autoři: Cousminer, Diana L., McCormack, Shana E., Mitchell, Jonathan A., Chesi, Alessandra, Kindler, Joseph M., Kelly, Andrea, Voight, Benjamin F., Kalkwarf, Heidi J., Lappe, Joan M., Shepherd, John A., Oberfield, Sharon E., Gilsanz, Vicente, Zemel, Babette S., Grant, Struan F. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800229/
https://ncbi.nlm.nih.gov/pubmed/30711642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.01.026
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