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3348 Structural Determinants of Neoantigen Immunogenicity for Cancer Therapy

OBJECTIVES/SPECIFIC AIMS: We are exploring the structure of the interaction between an immunogenic neoantigen and a T cell receptor (TCR) that recognizes the neoantigen while tolerating the counterpart self antigen. No structural example exists to date of how a TCR can discriminate between a neoanti...

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Bibliografske podrobnosti
izdano v:J Clin Transl Sci
Main Authors: Devlin, Jason, Bobisse, Sara, Harari, Alexandre, Baker, Brian
Format: Artigo
Jezik:Inglês
Izdano: Cambridge University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799638/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.54
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