2165 Vesicular secretion of suppressor of cytokine signaling 3 by alveolar macrophages is dysregulated in NSCLC patients and its provision inhibits epithelial cell transformation and tumor cell function

OBJECTIVES/SPECIFIC AIMS: Insufficient endogenous expression of suppressor of cytokine signaling 3 (SOCS3) with subsequent over-activation of its target, the transcription factor STAT3, has been associated with tumorigenesis and cancer development in the lung and other organs. We have observed that...

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Bibliografiske detaljer
Udgivet i:J Clin Transl Sci
Main Authors: Speth, Jennifer, Penke, Loka R., Bazzill, Joseph, Arenberg, Douglas A., Moon, James J., Keshamouni, Venkateshwar G., Lama, Vibha N., Peters-Golden, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Cambridge University Press 2018
Fag:
Basic/Translational Science/Team Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799327/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2018.148
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