Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

BACKGROUND: Patients with haematological malignancies are often vitamin C deficient, and vitamin C is essential for the TET-induced conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), the first step in active DNA demethylation. Here, we investigate whether oral vitamin C suppleme...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Gillberg, Linn, Ørskov, Andreas D., Nasif, Ammar, Ohtani, Hitoshi, Madaj, Zachary, Hansen, Jakob W., Rapin, Nicolas, Mogensen, Johanne B., Liu, Minmin, Dufva, Inge H., Lykkesfeldt, Jens, Hajkova, Petra, Jones, Peter A., Grønbæk, Kirsten
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798470/
https://ncbi.nlm.nih.gov/pubmed/31623675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0739-5
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