Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion

BACKGROUND: Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative medicine. However, long-term in vitro passaging leads to stemness loss and cell senescence of ADSCs, resulting in failure of ADSC-based therapy. METHODS: In this study, ADSCs were treated with...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Liao, Naishun, Shi, Yingjun, Zhang, Cuilin, Zheng, Youshi, Wang, Yingchao, Zhao, Bixing, Zeng, Yongyi, Liu, Xiaolong, Liu, Jingfeng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798439/
https://ncbi.nlm.nih.gov/pubmed/31623678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1404-9
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