In Vitro Double-Stranded RNA Synthesis by Rotavirus Polymerase Mutants with Lesions at Core Shell Contact Sites

The rotavirus polymerase VP1 mediates all stages of viral RNA synthesis within the confines of subviral particles and while associated with the core shell protein VP2. Transcription (positive-strand RNA [+RNA] synthesis) by VP1 occurs within double-layered particles (DLPs), while genome replication...

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Bibliographic Details
Published in:J Virol
Main Authors: Steger, Courtney L., Brown, Mackenzie L., Sullivan, Owen M., Boudreaux, Crystal E., Cohen, Courtney A., LaConte, Leslie E. W., McDonald, Sarah M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798093/
https://ncbi.nlm.nih.gov/pubmed/31341048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01049-19
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