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Global Dynamics of Yeast Hsp90 Middle and C-Terminal Dimer Studied by Advanced Sampling Simulations

The Hsp90 protein complex is one of the most abundant molecular chaperone proteins that assists in folding of a variety of client proteins. During its functional cycle it undergoes large domain rearrangements coupled to the hydrolysis of ATP and association or dissociation of domain interfaces. In o...

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Bibliografski detalji
Izdano u:Front Mol Biosci
Glavni autori: Kandzia, Florian, Ostermeir, Katja, Zacharias, Martin
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798034/
https://ncbi.nlm.nih.gov/pubmed/31681792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00093
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