A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice

Mutations in Tbr1, a high-confidence ASD (autism spectrum disorder)-risk gene encoding the transcriptional regulator TBR1, have been shown to induce diverse ASD-related molecular, synaptic, neuronal, and behavioral dysfunctions in mice. However, whether Tbr1 mutations derived from autistic individua...

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Foilsithe in:Front Mol Neurosci
Main Authors: Yook, Chaehyun, Kim, Kyungdeok, Kim, Doyoun, Kang, Hyojin, Kim, Sun-Gyun, Kim, Eunjoon, Kim, Soo Young
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797848/
https://ncbi.nlm.nih.gov/pubmed/31680851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00241
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