Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our understanding of this epigenetic mark remains insufficient. Here, we identify the native MORF complex as a histone H3K23-specific acetyltransfera...

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Udgivet i:Nat Commun
Main Authors: Klein, Brianna J., Jang, Suk Min, Lachance, Catherine, Mi, Wenyi, Lyu, Jie, Sakuraba, Shun, Krajewski, Krzysztof, Wang, Wesley W., Sidoli, Simone, Liu, Jiuyang, Zhang, Yi, Wang, Xiaolu, Warfield, Becka M., Kueh, Andrew J., Voss, Anne K., Thomas, Tim, Garcia, Benjamin A., Liu, Wenshe R., Strahl, Brian D., Kono, Hidetoshi, Li, Wei, Shi, Xiaobing, Côté, Jacques, Kutateladze, Tatiana G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797804/
https://ncbi.nlm.nih.gov/pubmed/31624313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12551-5
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