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Transforming protein-polymer conjugate purification by tuning protein solubility

Almost all commercial proteins are purified using ammonium sulfate precipitation. Protein-polymer conjugates are synthesized from pure starting materials, and the struggle to separate conjugates from polymer, native protein, and from isomers has vexed scientists for decades. We have discovered that...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Baker, Stefanie L., Munasinghe, Aravinda, Kaupbayeva, Bibifatima, Rebecca Kang, Nin, Certiat, Marie, Murata, Hironobu, Matyjaszewski, Krzysztof, Lin, Ping, Colina, Coray M., Russell, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797786/
https://ncbi.nlm.nih.gov/pubmed/31624254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12612-9
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