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Strategies to reduce genetic mosaicism following CRISPR-mediated genome edition in bovine embryos
Genetic mosaicism is the presence of more than two alleles on an individual and it is commonly observed following CRISPR microinjection of zygotes. This phenomenon appears when DNA replication precedes CRISPR-mediated genome edition and it is undesirable because it reduces greatly the odds for direc...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6797768/ https://ncbi.nlm.nih.gov/pubmed/31624292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51366-8 |
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