Inhibition of CD44 intracellular domain production suppresses bovine articular chondrocyte de-differentiation induced by excessive mechanical stress loading

CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. We hypothesized that mechanical stress-induced enhancement of CD44-intracellular domain (CD44-ICD) production plays an important role in the de-differentiation of chondrocytes and OA. This study aimed to assess the relat...

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Vydáno v:Sci Rep
Hlavní autoři: Sobue, Yasumori, Takahashi, Nobunori, Ohashi, Yoshifumi, Suzuki, Mochihito, Nishiume, Tsuyoshi, Kobayakawa, Tomonori, Terabe, Kenya, Knudson, Warren, Knudson, Cheryl, Ishiguro, Naoki, Kojima, Toshihisa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797729/
https://ncbi.nlm.nih.gov/pubmed/31624271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50166-4
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