Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions

Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and autoimmunity research cohorts, as well as vaccine efficacy trials. These studies often require small quantities of IgG to be purified from plasma for downstream analysis wit...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lopez, Ester, Scott, Nichollas E., Wines, Bruce D., Hogarth, P. Mark, Wheatley, Adam K., Kent, Stephen J., Chung, Amy W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797627/
https://ncbi.nlm.nih.gov/pubmed/31681303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02415
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