A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits...

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Pubblicato in:Cell Res
Autori principali: Xie, Bingqing, Sun, Da, Du, Yuanyuan, Jia, Jun, Sun, Shicheng, Xu, Jun, Liu, Yifang, Xiang, Chengang, Chen, Sitong, Xie, Huangfan, Wang, Qiming, Li, Guangya, LYU, Xuehui, Shen, Hui, Li, Shiyu, Wu, Min, Zhang, Xiaonan, Pu, Yue, Xiang, Kuanhui, Lai, Weifeng, Du, Peng, Yuan, Zhenghong, Li, Cheng, Shi, Yan, Lu, Shichun, Deng, Hongkui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796870/
https://ncbi.nlm.nih.gov/pubmed/31270412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0196-x
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