A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits...

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發表在:Cell Res
Main Authors: Xie, Bingqing, Sun, Da, Du, Yuanyuan, Jia, Jun, Sun, Shicheng, Xu, Jun, Liu, Yifang, Xiang, Chengang, Chen, Sitong, Xie, Huangfan, Wang, Qiming, Li, Guangya, LYU, Xuehui, Shen, Hui, Li, Shiyu, Wu, Min, Zhang, Xiaonan, Pu, Yue, Xiang, Kuanhui, Lai, Weifeng, Du, Peng, Yuan, Zhenghong, Li, Cheng, Shi, Yan, Lu, Shichun, Deng, Hongkui
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796870/
https://ncbi.nlm.nih.gov/pubmed/31270412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0196-x
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