Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis

Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effect...

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Vydáno v:Cell Res
Hlavní autoři: Zhong, Fudi, Hu, Zhigao, Jiang, Keqing, Lei, Biao, Wu, Zhan, Yuan, Guandou, Luo, Hongliang, Dong, Chunqiang, Tang, Bo, Zheng, Chaowen, Yang, Shuai, Zeng, Yonglian, Guo, Zhenya, Yu, Shuiping, Su, Huizhao, Zhang, Guo, Qiu, Xiaoqiang, Tomlinson, Stephen, He, Songqing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796853/
https://ncbi.nlm.nih.gov/pubmed/31076642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0175-2
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