Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus

BACKGROUND: NACHT and WD repeat domain-containing protein 1 (Nwd1) is a member of the innate immune protein subfamily. Nwd1 contributes to the androgen receptor signaling pathway and is involved in axonal growth. However, the mechanisms that underlie pathophysiological dysfunction in seizures remain...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Yang, Qin, Huang, Zifeng, Luo, Yangfu, Zheng, Fangshuo, Hu, Yida, Liu, Hui, Zhu, Shuzhen, He, Miaoqing, Xu, Demei, Li, Yun, Yang, Min, Yang, Yi, Wei, Xiaobo, Gao, Xiaoya, Wang, Wei, Ma, Junhong, Ma, Yuanlin, Wang, Xuefeng, Wang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796588/
https://ncbi.nlm.nih.gov/pubmed/31474551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.08.050
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