Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

BACKGROUND: NOS1AP is an adaptor protein and its SNP rs12742393 was associated with type 2 diabetes (T2D). However, it remains uncertain whether NOS1AP plays a role in regulation of insulin sensitivity. Hepatic insulin resistance contributed to the development of T2D. Here, our investigation was foc...

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Udgivet i:EBioMedicine
Main Authors: Mu, Kaida, Sun, Yun, Zhao, Yu, Zhao, Tianxue, Li, Qian, Zhang, Mingliang, Li, Huating, Zhang, Rong, Hu, Cheng, Wang, Chen, Jia, Weiping
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796549/
https://ncbi.nlm.nih.gov/pubmed/31473185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.08.033
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