Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function

AIMS/HYPOTHESIS: Adaptor protein, phosphotyrosine interaction, pleckstrin homology domain and leucine zipper containing 1 (APPL1) is an adapter protein that positively mediates adiponectin signalling. Deficiency of APPL1 in the target tissues of insulin induces insulin resistance. We therefore aimed...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Wang, Chen, Li, Xiaowen, Mu, Kaida, Li, Ling, Wang, Shihong, Zhu, Yunxia, Zhang, Mingliang, Ryu, Jiyoon, Xie, Zhifang, Shi, Dongyun, Zhang, Weiping J., Dong, Lily Q., Jia, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556236/
https://ncbi.nlm.nih.gov/pubmed/23793716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-2971-4
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