Antibody-dependent cellular cytotoxicity targeting CD4-inducible epitopes predicts mortality in HIV-infected infants

BACKGROUND: Antibody-dependent cellular cytotoxicity (ADCC) has been associated with improved infant outcome in mother-to-child transmission (MTCT) of HIV-1. Epitopes of these ADCC-mediating antibodies remain unidentified. CD4-inducible (CD4i) epitopes on gp120 are common ADCC targets in natural inf...

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Bibliografische gegevens
Gepubliceerd in:EBioMedicine
Hoofdauteurs: Naiman, Nicole E., Slyker, Jennifer, Richardson, Barbra A., John-Stewart, Grace, Nduati, Ruth, Overbaugh, Julie M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019
Onderwerpen:
Research paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796543/
https://ncbi.nlm.nih.gov/pubmed/31501077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.08.072
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