NP1 Regulates Neuronal Activity-Dependent Accumulation of BAX in Mitochondria and Mitochondrial Dynamics

In cultured cerebellar granule neurons, low neuronal activity triggers the intrinsic program of apoptosis, which requires protein synthesis-dependent BAX translocation to mitochondria, a process that may underlie neuronal damage in neurodegeneration. However, the mechanisms that link neuronal activi...

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Pubblicato in:J Neurosci
Autori principali: Clayton, Kevin B., Podlesniy, Petar, Figueiro-Silva, Joana, López-Doménech, Guillermo, Benitez, Lluis, Enguita, Marta, Abad, Maria A., Soriano, Eduardo, Trullas, Ramon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2012
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796267/
https://ncbi.nlm.nih.gov/pubmed/22279230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4604-11.2012
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