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Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice
Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 deficiency decreases the mRNA, protein and microsomal activity of Cyp3a11, and blunts their circ...
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| Pubblicato in: | Commun Biol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6795895/ https://ncbi.nlm.nih.gov/pubmed/31633069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0607-z |
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