Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence

We previously showed that curcumin, a phytopolyphenol found in turmeric (Curcuma longa), targets a series of enzymes in the ROS metabolic pathway, induces irreversible growth arrest, and causes apoptosis. In this study, we tested Pentagamavunon-1 (PGV-1), a molecule related to curcumin, for its inhi...

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Pubblicato in:Sci Rep
Autori principali: Lestari, Beni, Nakamae, Ikuko, Yoneda-Kato, Noriko, Morimoto, Tsumoru, Kanaya, Shigehiko, Yokoyama, Takashi, Shionyu, Masafumi, Shirai, Tsuyoshi, Meiyanto, Edy, Kato, Jun-ya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795878/
https://ncbi.nlm.nih.gov/pubmed/31619723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51244-3
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