Removal of the Potassium Chloride Co-Transporter from the Somatodendritic Membrane of Axotomized Motoneurons Is Independent of BDNF/TrkB Signaling But Is Controlled by Neuromuscular Innervation

The potassium-chloride cotransporter (KCC2) maintains the low intracellular chloride found in mature central neurons and controls the strength and direction of GABA/glycine synapses. We found that following axotomy as a consequence of peripheral nerve injuries (PNIs), KCC2 protein is lost throughout...

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Опубликовано в: :eNeuro
Главные авторы: Akhter, Erica Tracey, Griffith, Ronald W., English, Arthur W., Alvarez, Francisco J.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2019
Предметы:
New Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795555/
https://ncbi.nlm.nih.gov/pubmed/31541001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0172-19.2019
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