Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice

Recently we demonstrated that ablation of the DNA methyltransferase enzyme, Dnmt3b, resulted in catabolism and progression of osteoarthritis (OA) in murine articular cartilage through a mechanism involving increased mitochondrial respiration. In this study, we identify 4-aminobutyrate aminotransfera...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Shen, Jie, Wang, Cuicui, Ying, Jun, Xu, Taotao, McAlinden, Audrey, O’Keefe, Regis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795381/
https://ncbi.nlm.nih.gov/pubmed/31534049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128568
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